Butyl nitrite → 4-Chloro-5,6-dimethoxy-indan-1,2-dione 2-oxime

HRID 2101136Notes

Reaction equation

[Cl:1][C:2]1[C:10]([O:11][CH3:12])=[C:9]([O:13][CH3:14])[CH:8]=[C:7]2[C:3]=1[CH2:4][CH2:5][C:6]2=[O:15].C([O:20][N:21]=O)CCC>>[Cl:1][C:2]1[C:10]([O:11][CH3:12])=[C:9]([O:13][CH3:14])[CH:8]=[C:7]2[C:3]=1[CH2:4][C:5](=[N:21][OH:20])[C:6]2=[O:15]

Participants

Reactant 2

HCID 10996Butyl nitrite

HCID 577996664-Chloro-5,6-dimethoxy-indan-1-one

Product 1

HCID 766087394-Chloro-5,6-dimethoxy-indan-1,2-dione 2-oxime

Procedure

Similar procedure as described in example 9B was used, starting from 4-Chloro-5,6-dimethoxy-indan-1-one and n-butylnitrite to give 4-Chloro-5,6-dimethoxy-indan-1,2-dione 2-oxime. LC-MS: m/e 256 (MH+).

Sources & evidence

ORD record: ord-22fdcb7f4cb44f4ebe73e3a940735f24
Source dataset: uspto-grants-2009_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07572809B2

Reaction notes

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