4-Toluenesulfonyl chloride → 3-Chloro-2-cyanomethyl-4,5-dimethoxy-benzoic acid

HRID 2101137Notes

Reaction equation

HRID 2101137 reaction equation
[Cl:1][C:2]1[C:10]([O:11][CH3:12])=[C:9]([O:13][CH3:14])[CH:8]=[C:7]2[C:3]=1[CH2:4][C:5](=[N:16]O)[C:6]2=[O:15].C1(C)C=CC(S(Cl)(=O)=[O:25])=CC=1>>[Cl:1][C:2]1[C:3]([CH2:4][C:5]#[N:16])=[C:7]([CH:8]=[C:9]([O:13][CH3:14])[C:10]=1[O:11][CH3:12])[C:6]([OH:15])=[O:25]

Participants

3

Reactant 2

HCID 73974-Toluenesulfonyl chlorideHCID 766087394-Chloro-5,6-dimethoxy-indan-1,2-dione 2-oxime

Product 1

HCID 577996033-Chloro-2-cyanomethyl-4,5-dimethoxy-benzoic acid

Procedure

Similar procedure as described in example 9B was used, starting from 4-Chloro-5,6-dimethoxy-indan-1,2-dione 2-oxime and p-Toluenesulfonyl chloride to give 3-Chloro-2-cyanomethyl-4,5-dimethoxy-benzoic acid. LC-MS: m/e 254 (M−1).

Sources & evidence

ORD record
ord-3fa819889852430aa95eda94f728341a
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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