1H-Pyrazol-3-amine, 5-methyl- → HCID 178486774, compound

HRID 2101138Notes

Reaction equation

HRID 2101138 reaction equation
[Cl:1][C:2]1[C:3]([CH2:15][C:16]#[N:17])=[C:4]([CH:8]=[C:9]([O:13][CH3:14])[C:10]=1[O:11][CH3:12])[C:5](O)=[O:6].[NH2:18][C:19]1[CH:23]=[C:22]([CH3:24])[NH:21][N:20]=1>C(O)(=O)C>[Cl:1][C:2]1[C:10]([O:11][CH3:12])=[C:9]([O:13][CH3:14])[CH:8]=[C:4]2[C:3]=1[CH:15]=[C:16]([NH:18][C:19]1[CH:23]=[C:22]([CH3:24])[NH:21][N:20]=1)[N:17]=[C:5]2[OH:6]

Participants

4

Reactant 2

HCID 931461H-Pyrazol-3-amine, 5-methyl-HCID 577996033-Chloro-2-cyanomethyl-4,5-dimethoxy-benzoic acid

Product 1

HCID 178486774HCID 178486774, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Similar procedure as described in example 9B was used, starting from 3-Chloro-2-cyanomethyl-4,5-dimethoxy-benzoic acid, 3-amino-5-methylpyrazol and acetic acid to give 5-Chloro-6,7-dimethoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-1-ol. LC-MS: m/e 335 (MH+).

Sources & evidence

ORD record
ord-a1524193587547f5980653257cf177f2
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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