4-Toluenesulfonyl chloride → 4-Bromo-2-(cyanomethyl)benzoic acid

HRID 2101142Notes

Reaction equation

HRID 2101142 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[C:7](=[O:11])[C:6](=[N:12]O)[CH2:5]2.C1(C)C=CC(S(Cl)(=O)=[O:21])=CC=1>>[Br:1][C:2]1[CH:10]=[CH:9][C:8]([C:7]([OH:11])=[O:21])=[C:4]([CH2:5][C:6]#[N:12])[CH:3]=1

Participants

3

Reactant 2

HCID 73974-Toluenesulfonyl chlorideHCID 76608754HCID 76608754, compound

Product 1

HCID 577994854-Bromo-2-(cyanomethyl)benzoic acid

Procedure

Similar procedure as described in example 9B was used, starting from 5-Bromo-indan-1,2-dione 2-oxime and p-Toluenesulfonyl chloride to give 4-Bromo-2-cyanomethyl-benzoic acid. LC-MS: m/e 238 (M−1).

Sources & evidence

ORD record
ord-cf132edfdeaf4a3fab3acb9425086115
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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