Phosphorus oxychloride → HCID 57799825, compound

HRID 2101144Notes

Reaction equation

HRID 2101144 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](O)=[N:7][C:6]([NH:13][C:14]1[CH:18]=[C:17]([CH3:19])[NH:16][N:15]=1)=[CH:5]2.O=P(Cl)(Cl)[Cl:22]>>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8]([Cl:22])=[N:7][C:6]([NH:13][C:14]1[CH:18]=[C:17]([CH3:19])[NH:16][N:15]=1)=[CH:5]2

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 178428170HCID 178428170, compound

Product 1

HCID 57799825HCID 57799825, compound

Procedure

Similar procedure as described in example 9B was used, starting from 6-Bromo-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-1-ol and POCl3 to give (6-Bromo-1-chloro-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine. LC-MS: m/e 337 (MH+).

Sources & evidence

ORD record
ord-57ef04d46b364b08ac73ff3bcef1f11a
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

Loading…