Isopropanol → HCID 57799819, compound

HRID 2101145Notes

Reaction equation

[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](Cl)=[N:7][C:6]([NH:13][C:14]1[CH:18]=[C:17]([CH3:19])[NH:16][N:15]=1)=[CH:5]2.[CH:20]([OH:23])([CH3:22])[CH3:21]>>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8]([O:23][CH:20]([CH3:22])[CH3:21])=[N:7][C:6]([NH:13][C:14]1[CH:18]=[C:17]([CH3:19])[NH:16][N:15]=1)=[CH:5]2

Participants

Reactant 2

HCID 3776Isopropanol

HCID 57799825HCID 57799825, compound

Product 1

HCID 57799819HCID 57799819, compound

Procedure

Similar procedure as described in example 376 was used, starting from (6-Bromo-1-chloro-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine and isopropanol to give (6-Bromo-1-isopropoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine. LC-MS: m/e 361 (MH+).

Sources & evidence

ORD record: ord-8deba9d9ac5b45bba863220b5c8f456d
Source dataset: uspto-grants-2009_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07572809B2

Reaction notes

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