1-(2-Methoxyethyl)piperazine → [1-Isopropoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-6-yl]-[4-(2-methoxy-ethyl)-piperazin-1-yl]-methanone
Reaction equation
[CH:1]([O:4][C:5]1[C:14]2[C:9](=[CH:10][C:11]([C:15](O)=[O:16])=[CH:12][CH:13]=2)[CH:8]=[C:7]([NH:18][C:19]2[CH:23]=[C:22]([CH3:24])[NH:21][N:20]=2)[N:6]=1)([CH3:3])[CH3:2].[CH3:25][O:26][CH2:27][CH2:28][N:29]1[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]1>>[CH:1]([O:4][C:5]1[C:14]2[C:9](=[CH:10][C:11]([C:15]([N:32]3[CH2:33][CH2:34][N:29]([CH2:28][CH2:27][O:26][CH3:25])[CH2:30][CH2:31]3)=[O:16])=[CH:12][CH:13]=2)[CH:8]=[C:7]([NH:18][C:19]2[CH:23]=[C:22]([CH3:24])[NH:21][N:20]=2)[N:6]=1)([CH3:3])[CH3:2]Participants
3
Procedure
Similar procedure as described in example 384 was used, starting from 1-Isopropoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinoline-6-carboxylic acid and 1-(2-Methoxy-ethyl)-piperazine to give [1-Isopropoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-6-yl]-[4-(2-methoxy-ethyl)-piperazin-1-yl]-methanone. LC-MS: m/e 453 (MH+).
Sources & evidence
- ORD record
- ord-5adfc910b31f40bcbba320a500a1ef60
- Source dataset
- uspto-grants-2009_08
- Patent number
- US07572809B2
Reaction notes
Loading…