Pyrrolidine → HCID 57799682, compound

HRID 2101160Notes

Reaction equation

HRID 2101160 reaction equation
[CH:1]([O:4][C:5]1[C:14]2[C:9](=[CH:10][C:11]([C:15](O)=[O:16])=[CH:12][CH:13]=2)[CH:8]=[C:7]([NH:18][C:19]2[CH:23]=[C:22]([CH3:24])[NH:21][N:20]=2)[N:6]=1)([CH3:3])[CH3:2].[NH:25]1[CH2:29][CH2:28][CH2:27][CH2:26]1>>[CH:1]([O:4][C:5]1[C:14]2[C:9](=[CH:10][C:11]([C:15]([N:25]3[CH2:29][CH2:28][CH2:27][CH2:26]3)=[O:16])=[CH:12][CH:13]=2)[CH:8]=[C:7]([NH:18][C:19]2[CH:23]=[C:22]([CH3:24])[NH:21][N:20]=2)[N:6]=1)([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 577994701-Isopropoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinoline-6-carboxylic acid

Product 1

HCID 57799682HCID 57799682, compound

Procedure

Similar procedure as described in example 384 was used, starting from 1-Isopropoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinoline-6-carboxylic acid and Pyrrolidine to give [1-Isopropoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-6-yl]-pyrrolidin-1-yl-methanone. LC-MS: m/e 394 (MH+).

Sources & evidence

ORD record
ord-a825c6f15c6f4380bc6583ac06b202e8
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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