4-Toluenesulfonyl chloride → 5-Bromo-2-(cyanomethyl)-4-methoxybenzoic acid
Reaction equation
[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][C:7](=[N:12]O)[C:8]2=[O:11])=[CH:4][C:3]=1[O:14][CH3:15].C1(C)C=CC(S(Cl)(=O)=[O:23])=CC=1>>[Br:1][C:2]1[C:3]([O:14][CH3:15])=[CH:4][C:5]([CH2:6][C:7]#[N:12])=[C:9]([CH:10]=1)[C:8]([OH:11])=[O:23]Participants
3
Procedure
Similar procedure as described in example 9B was used, starting from 6-Bromo-5-methoxy-indan-1,2-dione 2-oxime and p-Toluenesulfonyl chloride to give 5-Bromo-2-cyanomethyl-4-methoxy-benzoic acid. LC-MS: m/e 268 (M−1).
Sources & evidence
- ORD record
- ord-d200e1339bb544c695916e3018c8a07e
- Source dataset
- uspto-grants-2009_08
- Patent number
- US07572809B2
Reaction notes
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