HCID 57799591, compound → HCID 57799546, compound

HRID 2101165Notes

Reaction equation

HRID 2101165 reaction equation
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[C:7]([NH:13][C:14]3[CH:18]=[C:17]([CH3:19])[NH:16][N:15]=3)[N:8]=[C:9]2Cl)=[CH:4][C:3]=1[O:20][CH3:21]>C(O)(C)C>[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[C:7]([NH:13][C:14]3[CH:18]=[C:17]([CH3:19])[NH:16][N:15]=3)[N:8]=[C:9]2[O:20][CH:3]([CH3:4])[CH3:2])=[CH:4][C:3]=1[O:20][CH3:21]

Participants

3

Reactant 1

HCID 57799591HCID 57799591, compound

Product 1

HCID 57799546HCID 57799546, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

Similar procedure as described in example 376 was used, starting from (7-Bromo-1-chloro-6-methoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine and isopropanol to give (7-Bromo-1-isopropoxy-6-methoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine. LC-MS: m/e 391 (MH+).

Sources & evidence

ORD record
ord-894b1f6174ab4c1c8feda22e0e437c0f
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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