Phosphorus oxychloride → HCID 57799703, compound

HRID 2101169Notes

Reaction equation

HRID 2101169 reaction equation
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[C:7]([NH:13][C:14]3[CH:18]=[C:17]([CH3:19])[NH:16][N:15]=3)[N:8]=[C:9]2O)=[CH:4][CH:3]=1.O=P(Cl)(Cl)[Cl:22]>>[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[C:7]([NH:13][C:14]3[CH:18]=[C:17]([CH3:19])[NH:16][N:15]=3)[N:8]=[C:9]2[Cl:22])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 178428171HCID 178428171, compound

Product 1

HCID 57799703HCID 57799703, compound

Procedure

Similar procedure as described in example 9B was used, starting from 7-Bromo-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-1-ol and POCl3 to give (7-Bromo-1-chloro-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine. LC-MS: m/e 337 (MH+).

Sources & evidence

ORD record
ord-49ed765ddf0942ea94effeb7084438c9
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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