Isopropanol → HCID 57799480, compound

HRID 2101170Notes

Reaction equation

[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[C:7]([NH:13][C:14]3[CH:18]=[C:17]([CH3:19])[NH:16][N:15]=3)[N:8]=[C:9]2Cl)=[CH:4][CH:3]=1.[CH:20]([OH:23])([CH3:22])[CH3:21]>>[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[C:7]([NH:13][C:14]3[CH:18]=[C:17]([CH3:19])[NH:16][N:15]=3)[N:8]=[C:9]2[O:23][CH:20]([CH3:22])[CH3:21])=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 3776Isopropanol

HCID 57799703HCID 57799703, compound

Product 1

HCID 57799480HCID 57799480, compound

Procedure

Similar procedure as described in example 376 was used, starting from (7-Bromo-1-chloro-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine and isopropanol to give (7-Bromo-1-isopropoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine. LC-MS: m/e 361 (MH+).

Sources & evidence

ORD record: ord-7b24c7aba11d46aabd2d22a3e3f443ba
Source dataset: uspto-grants-2009_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07572809B2

Reaction notes

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