5-chloro-6-fluoro-1H-indole-7-carboxylic acid → 5-Chloro-6-fluoro-1H-indole-7-carboxylic acid [2-(3,4-dichloro-phenyl)-ethyl]-(4-tri-methylsilanyl-benzyl)-amide

HRID 2101263Notes

Reaction equation

HRID 2101263 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([C:12]([OH:14])=O)[C:10]=1[F:11])[NH:7][CH:6]=[CH:5]2.[Cl:15][C:16]1[CH:17]=[C:18]([CH2:23][CH2:24][NH:25][CH2:26][C:27]2[CH:32]=[CH:31][C:30]([Si:33]([CH3:36])([CH3:35])[CH3:34])=[CH:29][CH:28]=2)[CH:19]=[CH:20][C:21]=1[Cl:22]>>[Cl:15][C:16]1[CH:17]=[C:18]([CH2:23][CH2:24][N:25]([CH2:26][C:27]2[CH:28]=[CH:29][C:30]([Si:33]([CH3:34])([CH3:36])[CH3:35])=[CH:31][CH:32]=2)[C:12]([C:9]2[C:10]([F:11])=[C:2]([Cl:1])[CH:3]=[C:4]3[C:8]=2[NH:7][CH:6]=[CH:5]3)=[O:14])[CH:19]=[CH:20][C:21]=1[Cl:22]

Participants

3

Reactant 2

HCID 251136475-chloro-6-fluoro-1H-indole-7-carboxylic acidHCID 57438504[2-(3,4-Dichloro-phenyl)-ethyl]-(4-trimethylsilanyl-benzyl)-amine

Product 1

HCID 247799785-Chloro-6-fluoro-1H-indole-7-carboxylic acid [2-(3,4-dichloro-phenyl)-ethyl]-(4-tri-methylsilanyl-benzyl)-amide

Procedure

5-Chloro-6-fluoro-1H-indole-7-carboxylic acid [2-(3,4-dichloro-phenyl)-ethyl]-(4-trimethylsilanyl-benzyl)-amide was prepared in analogy to example 1 from 5-chloro-6-fluoro-1H-indole-7-carboxylic acid and [2-(3,4-dichloro-phenyl)-ethyl]-(4-trimethylsilanyl-benzyl)-amine. MS (ISP) 547.2/549.3/551.3 (96/100/37) (M+H)+.

Sources & evidence

ORD record
ord-ac9208f315d9428cbd478fef6af1b4de
Source dataset
uspto-grants-2009_08
Patent number
US07572823B2

Reaction notes

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