5-chloro-6-fluoro-1H-indole-7-carboxylic acid → 5-Chloro-6-fluoro-1H-indole-7-carboxylic acid [2-(4-fluoro-phenyl)-ethyl]-(4-trimethylsilanyl-benzyl)-amide

HRID 2101269Notes

Reaction equation

HRID 2101269 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([C:12]([OH:14])=O)[C:10]=1[F:11])[NH:7][CH:6]=[CH:5]2.[F:15][C:16]1[CH:21]=[CH:20][C:19]([CH2:22][CH2:23][NH:24][CH2:25][C:26]2[CH:31]=[CH:30][C:29]([Si:32]([CH3:35])([CH3:34])[CH3:33])=[CH:28][CH:27]=2)=[CH:18][CH:17]=1>>[F:15][C:16]1[CH:17]=[CH:18][C:19]([CH2:22][CH2:23][N:24]([CH2:25][C:26]2[CH:27]=[CH:28][C:29]([Si:32]([CH3:33])([CH3:35])[CH3:34])=[CH:30][CH:31]=2)[C:12]([C:9]2[C:10]([F:11])=[C:2]([Cl:1])[CH:3]=[C:4]3[C:8]=2[NH:7][CH:6]=[CH:5]3)=[O:14])=[CH:20][CH:21]=1

Participants

3

Reactant 2

HCID 251136475-chloro-6-fluoro-1H-indole-7-carboxylic acidHCID 57438507HCID 57438507, compound

Product 1

HCID 247799805-Chloro-6-fluoro-1H-indole-7-carboxylic acid [2-(4-fluoro-phenyl)-ethyl]-(4-trimethylsilanyl-benzyl)-amide

Procedure

5-Chloro-6-fluoro-1H-indole-7-carboxylic acid [2-(4-fluoro-phenyl)-ethyl]-(4-trimethylsilanyl-benzyl)-amide was prepared in analogy to example 1 from 5-chloro-6-fluoro-1H-indole-7-carboxylic acid and [2-(4-fluoro-phenyl)-ethyl]-(4-trimethylsilanyl-benzyl)-amine. MS (ISP) 497.4/499.3 (100/48) (M+H)+.

Sources & evidence

ORD record
ord-d95c64a3110b43a4b9e7fa0090ddc097
Source dataset
uspto-grants-2009_08
Patent number
US07572823B2

Reaction notes

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