p-Fluorophenethylamine → HCID 57438507, compound

HRID 2101270Notes

Reaction equation

HRID 2101270 reaction equation
[CH3:1][Si:2]([CH3:12])([CH3:11])[C:3]1[CH:10]=[CH:9][C:6]([CH:7]=O)=[CH:5][CH:4]=1.[F:13][C:14]1[CH:19]=[CH:18][C:17]([CH2:20][CH2:21][NH2:22])=[CH:16][CH:15]=1>>[F:13][C:14]1[CH:19]=[CH:18][C:17]([CH2:20][CH2:21][NH:22][CH2:7][C:6]2[CH:9]=[CH:10][C:3]([Si:2]([CH3:12])([CH3:11])[CH3:1])=[CH:4][CH:5]=2)=[CH:16][CH:15]=1

Participants

3

Reactant 2

HCID 4653p-FluorophenethylamineHCID 6375734-(Trimethylsilyl)benzaldehyde

Product 1

HCID 57438507HCID 57438507, compound

Procedure

[2-(4-fluoro-phenyl)-ethyl]-(4-trimethylsilanyl-benzyl)-amine was prepared in analogy to example 1 from 4-trimethylsilanyl-benzaldehyde and 2-(4-fluoro-phenyl)-ethylamine. MS (ISP): 302.2 (100) (M+H)+. 1H NMR (CDCl3, 300 MHz): δ 7.47 (d, 2H), 7.27 (d, 2H), 7.15 (dd, 2H), 6.97 (dt, 2H) 3.79 (s, 2H), 2.75-3.00 (m, 4H), 0.26 (s, 9H).

Sources & evidence

ORD record
ord-97c9275eebd0421684e5020ca4098fd6
Source dataset
uspto-grants-2009_08
Patent number
US07572823B2

Reaction notes

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