反应详情

To a stirring solution of 2-chloro-4-(4-chlorophenyl)-3,4′-bipyridine (1.3 g, 4.3 mmol) in pyridine (5 mL) at room temperature under argon was added hydrazine monohydrate (2.5 mL, 51.5 mmol). The reaction mixture was stirred at reflux under argon for 15 h. After cooling the reaction mixture to room temperature, most of the solvent was removed under reduced pressure. Water (25 mL) was added to the residue while stirring and a precipitate formed. The precipitate was collected by filtration and washed with water (15 mL×2). After drying under reduced pressure at elevated temperature, 1.0 g of the title compound was obtained as a yellow solid. HPLC/MS: retention time=1.68 min, [M+H]+=297.

1. temperatureat reflux under argon for 15 h
2. custommost of the solvent was removed under reduced pressure
3. additionWater (25 mL) was added to the residue
4. stirringwhile stirring
5. customa precipitate formed
6. filtrationThe precipitate was collected by filtration
7. washwashed with water (15 mL×2)
8. customAfter drying under reduced pressure at elevated temperature