Tetrahydrofuran → tert-Butyl 4-(3,4-dichlorophenyl)-4-hydroxypiperidine-1-carboxylate

HRID 210135Notes

Reaction equation

HRID 210135 reaction equation
[Br:6][c:7]1[cH:8][c:9]([Cl:14])[c:10]([Cl:13])[cH:11][cH:12]1.[CH2:29]1[O:30][CH2:31][CH2:32][CH2:33]1.[CH3:1][CH2:2][CH2:3][CH2:4][Li:5].[O:15]=[C:16]1[CH2:17][CH2:18][N:19]([C:22](=[O:23])[O:24][C:25]([CH3:26])([CH3:27])[CH3:28])[CH2:20][CH2:21]1>>[c:7]1([C:16]2([OH:15])[CH2:17][CH2:18][N:19]([C:22](=[O:23])[O:24][C:25]([CH3:26])([CH3:27])[CH3:28])[CH2:20][CH2:21]2)[cH:8][c:9]([Cl:14])[c:10]([Cl:13])[cH:11][cH:12]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 290134-Bromo-1,2-dichlorobenzeneHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylateHCID 178418339Butyllithium

Product 1

HCID 49760236tert-Butyl 4-(3,4-dichlorophenyl)-4-hydroxypiperidine-1-carboxylate

Sources & evidence

ORD record
ord-c3151a255564445d892be44fec35742f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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