8-bromo-7-(4-chlorophenyl)-5-methyl-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one → 6-bromo-7-(4-chlorophenyl)-5-methyl-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one

HRID 2101388Notes

Reaction equation

HRID 2101388 reaction equation
[Br:1][C:2]1[C:3]([CH3:17])=[N:4][C:5]([NH:15][NH2:16])=[CH:6][C:7]=1[C:8]1[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=1.BrC1C2N([C:33](=[O:36])NN=2)C(C)=CC=1C1C=CC(Cl)=CC=1>>[Br:1][C:2]1[C:7]([C:8]2[CH:9]=[CH:10][C:11]([Cl:14])=[CH:12][CH:13]=2)=[CH:6][C:5]2[N:4]([C:33](=[O:36])[NH:16][N:15]=2)[C:3]=1[CH3:17]

Participants

3

Reactant 2

HCID 577994038-bromo-7-(4-chlorophenyl)-5-methyl-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-oneHCID 577994103-Bromo-4-(4-chlorophenyl)-6-hydrazinyl-2-methylpyridine

Product 1

HCID 577993786-bromo-7-(4-chlorophenyl)-5-methyl-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-oneYield 96%

Procedure

The title compound (125 mg, 96% yield) as a pale yellow solid was prepared from 3-bromo-4-(4-chlorophenyl)-6-hydrazinyl-2-methylpyridine (120 mg, 0.384 mmol) by procedures analogous to those used for the preparation of 8-bromo-7-(4-chlorophenyl)-5-methyl-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one. HPLC/MS: retention time=3.65 min, [M+H]+=338.2.

Sources & evidence

ORD record
ord-6bad32e009c840f8910dbe04b52eba4d
Source dataset
uspto-grants-2009_08
Patent number
US07572808B2

Reaction notes

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