Methanol → HCID 22591541, compound

HRID 2101455Notes

Reaction equation

HRID 2101455 reaction equation
[Na].CO[C:4]1[N:5]=[N:6][C:7]([S:10]([C:13]2[N:14](S(C3C=CC=CC=3)(=O)=O)[C:15]3[C:20]([CH:21]=2)=[CH:19][CH:18]=[CH:17][CH:16]=3)(=[O:12])=[O:11])=[CH:8][CH:9]=1.[CH3:31][OH:32]>>[CH3:31][O:32][N:5]1[CH:4]=[CH:9][CH:8]=[C:7]([S:10]([C:13]2[NH:14][C:15]3[C:20]([CH:21]=2)=[CH:19][CH:18]=[CH:17][CH:16]=3)(=[O:11])=[O:12])[NH:6]1

Participants

4

Reactant 3

HCID 887MethanolHCID 5360545SodiumHCID 22591544HCID 22591544, compound

Product 1

HCID 22591541HCID 22591541, compoundYield 82%

Procedure

To a solution of sodium metal (18.6 mmol, 428 mg) dissolved in methanol (8 mL) was added a solution of 3-methoxy-6-(N-phenylsulfonylindole-2-sulfonyl)-pyridazine (1.86 mmol, 850 mg) and the reaction was stirred for 10 minutes. The reaction mixture was quenched with H2O (10 mL) and CHCl3 (25 mL). The CHCl3 layer was collected, dried, filtered, and the filtrate was evaporated to obtain 2-methoxy-6-(indole-2-sulfonyl)-pyridazine (82%, 440 mg).

Workup

  1. customThe reaction mixture was quenched with H2O (10 mL) and CHCl3 (25 mL)
  2. customThe CHCl3 layer was collected
  3. customdried
  4. filtrationfiltered
  5. customthe filtrate was evaporated

Sources & evidence

ORD record
ord-e23684678d3148af9808a1e5b33ec355
Source dataset
uspto-grants-2009_08
Patent number
US07572910B2

Reaction notes

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