HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfuryl chloride → HCID 18755695, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfuryl chloride | HCID 24648 | — |
| Reactant | Pyridine-3-sulfonyl chloride | HCID 3164136 | — |
| Reactant | 5-Isoquinolinesulfonyl chloride | HCID 3371655 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | HCID 18755695 | HCID 18755695 | — |
Reaction Steps
Referring to the scheme for Method 9, an amine 25 is reacted with a sulfonyl chloride such as 5-isoquinolinesulfonyl chloride, 3-pyridinesulfonyl chloride, etc., in the presence of a base such as triethylamine to give a sulfonylpiperidine, 26. The amino nitrogen is then deprotected by removal of the Z group to afford a compound of formula IV.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07572913B2 |
| Source dataset | uspto-grants-2009_08 |
| ORD ID | ord-917f51cac85b4483aba4ec846a8e012d |
| Source note | uspto-grants-2009_08 |