Sulfuryl chloride → HCID 18755695, compound

HRID 2101477Notes

Reaction equation

HRID 2101477 reaction equation
[S:1](Cl)(Cl)(=[O:3])=[O:2].[CH:6]1[C:15]2C=CC=C(S(Cl)(=O)=O)[C:10]=2[CH:9]=[CH:8][N:7]=1.N1C=CC=C(S(Cl)(=O)=O)C=1>C(N(CC)CC)C>[S:1](=[C:6]1[CH2:15][CH2:10][CH2:9][CH2:8][NH:7]1)(=[O:3])=[O:2]

Participants

5

Reactant 3

HCID 24648Sulfuryl chlorideHCID 3164136Pyridine-3-sulfonyl chlorideHCID 33716555-Isoquinolinesulfonyl chloride

Product 1

HCID 18755695HCID 18755695, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

Referring to the scheme for Method 9, an amine 25 is reacted with a sulfonyl chloride such as 5-isoquinolinesulfonyl chloride, 3-pyridinesulfonyl chloride, etc., in the presence of a base such as triethylamine to give a sulfonylpiperidine, 26. The amino nitrogen is then deprotected by removal of the Z group to afford a compound of formula IV.

Sources & evidence

ORD record
ord-917f51cac85b4483aba4ec846a8e012d
Source dataset
uspto-grants-2009_08
Patent number
US07572913B2

Reaction notes

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