反应详情

温度

70 °C

N-[1-(3,5-Dichloro-benzyl)-1H-imidazol-2-yl]-benzamide, was dissolved in anhydrous THF and 1M LiAlH4 was added to the reaction solution at room temperature. The reaction mixture was then heated to 70° C. and stirred for 10 min. The mixture was then diluted with CH2Cl2 and water was slowly added until H2 formation stopped. The reaction mixture was passed through a cartridge packed with anhydrous Na2SO4. The filtrated was concentrated and purified by silica gel preparative TLC using 95:5 CH2Cl2:MeOH to afford the title compound (5 mg, 7%); MS m/z 332 [C17H15Cl2N3+H]+.

1. additionwas slowly added until H2 formation
2. concentrationThe filtrated was concentrated
3. custompurified by silica gel preparative TLC