4-Fluorophenol → 2-(4-Fluoro-phenoxymethyl)-1H-imidazole

HRID 2101514Notes

Reaction equation

HRID 2101514 reaction equation
CO[C:3]1[CH:4]=[C:5]([CH:13]=[CH:14][CH:15]=1)[O:6][CH2:7][C:8]1[NH:9][CH:10]=[CH:11][N:12]=1.[F:16]C1C=CC(O)=CC=1>>[F:16][C:15]1[CH:14]=[CH:13][C:5]([O:6][CH2:7][C:8]2[NH:9][CH:10]=[CH:11][N:12]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 97324-FluorophenolHCID 578014922-(3-methoxy-phenoxymethyl)-1H-imidazole

Product 1

HCID 578015272-(4-Fluoro-phenoxymethyl)-1H-imidazole

Procedure

2-(4-Fluoro-phenoxymethyl)-1H-imidazole was prepared following a similar procedure for the preparation of 2-(3-Methoxy-phenoxymethyl)-1H-imidazole (see Example 18) using 4-fluorophenol in place of 3-methoxyphenol to provide a white solid (1.69 g, 85% for 2 steps); ESI MS m/z 193 [C10H9FN2O+H]+.

Workup

  1. customto provide a white solid (1.69 g, 85% for 2 steps)

Sources & evidence

ORD record
ord-e9d2e7b1cd004b4c83a166cb96acf7d1
Source dataset
uspto-grants-2009_08
Patent number
US07572921B2

Reaction notes

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