Potassium Cation → 6-Bromo-2-(3-{[tert-butyl(dimethyl)silyl]oxy}-2,2-dimethylpropyl)isoquinolin-1(2H)-one

HRID 210164Notes

Reaction equation

HRID 210164 reaction equation
[Br:19][CH2:20][C:21]([CH2:22][O:23][Si:24]([CH3:25])([CH3:26])[C:27]([CH3:28])([CH3:29])[CH3:30])([CH3:31])[CH3:32].[Br:1][c:2]1[cH:3][c:4]2[cH:5][cH:6][nH:7][c:8](=[O:12])[c:9]2[cH:10][cH:11]1.[C:13](=[O:14])([O-:15])[O-:16].[CH3:33][N:34]1[CH2:35][CH2:36][CH2:37][C:38]1=[O:39].[K+:17].[K+:18].[OH2:40]>>[Br:1][c:2]1[cH:3][c:4]2[cH:5][cH:6][n:7]([CH2:20][C:21]([CH2:22][O:23][Si:24]([CH3:25])([CH3:26])[C:27]([CH3:28])([CH3:29])[CH3:30])([CH3:31])[CH3:32])[c:8](=[O:12])[c:9]2[cH:10][cH:11]1

Participants

7

Reactant 6

HCID 813Potassium Cation2×HCID 962WaterHCID 13387N-methyl-2-pyrrolidoneHCID 19660Carbonate IonHCID 11780954(3-Bromo-2,2-dimethylpropoxy)(tert-butyl)dimethylsilaneHCID 158851826-Bromoisoquinolin-1(2H)-one

Product 1

HCID 671303156-Bromo-2-(3-{[tert-butyl(dimethyl)silyl]oxy}-2,2-dimethylpropyl)isoquinolin-1(2H)-one

Sources & evidence

ORD record
ord-1044975824374d8fac93f1026de0ebf0
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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