反应详情

Oxone (0.22 g) was added portionwise to a stirred solution of Example 575 (0.035 g) in N,N-dimethylformamide (4 ml). The mixture was stirred at room temperature under nitrogen for 24 h, a further portion of oxone (0.17 g) was added, and the mixture stirred for a further 5 h. The reaction was quenched with a solution of sodium sulphite (1.2 g) in water (15 ml), diluted with water (10 ml) and extracted with ethyl acetate (3×30 ml). The combined organic extracts were dried over magnesium sulphate and concentrated in vacuo to give the title compound as a buff solid (0.035 g).

1. stirringthe mixture stirred for a further 5 h
2. customThe reaction was quenched with a solution of sodium sulphite (1.2 g) in water (15 ml)
3. additiondiluted with water (10 ml)
4. extractionextracted with ethyl acetate (3×30 ml)
5. dry with materialThe combined organic extracts were dried over magnesium sulphate
6. concentrationconcentrated in vacuo