HuagongsheHuagongshe Chemistry Print Report · For research reference only
N,N-Dimethylformamide--water (1/1) → 3-Cyclopropyl-3-(4-hydroxyphenyl)propanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N,N-Dimethylformamide--water (1/1) | HCID 21962138 | — |
| Reactant | 5-(Cyclopropyl(4-hydroxyphenyl)methyl)-2,2-dimethyl-1,3-dioxane-4,6-dione | HCID 57672484 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 3-Cyclopropyl-3-(4-hydroxyphenyl)propanoic acid | HCID 57672525 | — |
Reaction Steps
A solution of 21.2 in 10:1 DMF/water (48 mL) was stirred overnight at 90° C. The mixture was cooled to room temperature, diluted with EtOAc, washed with 1 N HCl and brine, dried (MgSO4), and concentrated to afford 21.3. The crude product was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07572934B2 |
| Source dataset | uspto-grants-2009_08 |
| ORD ID | ord-c9b43c88a22a4f5db78d5fad178d2fde |
| Source note | uspto-grants-2009_08 |