4-chloro-2-(difluoromethyl)-1H-indole-5-carbonitrile → 4-Chloro-2-(difluoromethyl)-1-{2-[(6-fluoro-3-pyridinyl)oxy]ethyl}-1H-indole-5-carbonitrile

HRID 2101857Notes

Reaction equation

HRID 2101857 reaction equation
[Cl:1][C:2]1[C:10]([C:11]#[N:12])=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[C:5]([CH:13]([F:15])[F:14])[NH:6]2.Br[CH2:17][CH2:18][O:19][C:20]1[CH:21]=[CH:22][C:23]([F:26])=[N:24][CH:25]=1>>[Cl:1][C:2]1[C:10]([C:11]#[N:12])=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[C:5]([CH:13]([F:14])[F:15])[N:6]2[CH2:17][CH2:18][O:19][C:20]1[CH:25]=[N:24][C:23]([F:26])=[CH:22][CH:21]=1

Participants

3

Reactant 2

HCID 249856324-chloro-2-(difluoromethyl)-1H-indole-5-carbonitrileHCID 67405380Pyridine, 5-(2-bromoethoxy)-2-fluoro-

Product 1

HCID 249861254-Chloro-2-(difluoromethyl)-1-{2-[(6-fluoro-3-pyridinyl)oxy]ethyl}-1H-indole-5-carbonitrile

Procedure

Synthesized as described in Example 39 from 4-chloro-2-(difluoromethyl)-1H-indole-5-carbonitrile and 5-[(2-bromoethyl)oxy]-2-fluoropyridine: MS (ESI) m/z 366 (M+1).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-f949e6d68d5745f884fb53d6f13e7ec9
Source dataset
uspto-grants-2009_08
Patent number
US07572820B2

Reaction notes

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