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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2101857Generated: October 27, 2026

4-chloro-2-(difluoromethyl)-1H-indole-5-carbonitrile → 4-Chloro-2-(difluoromethyl)-1-{2-[(6-fluoro-3-pyridinyl)oxy]ethyl}-1H-indole-5-carbonitrile

https://huagongshe.com/reaction/2101857

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-chloro-2-(difluoromethyl)-1H-indole-5-carbonitrileHCID 24985632—
ReactantPyridine, 5-(2-bromoethoxy)-2-fluoro-HCID 67405380—
Product4-Chloro-2-(difluoromethyl)-1-{2-[(6-fluoro-3-pyridinyl)oxy]ethyl}-1H-indole-5-carbonitrileHCID 24986125—

Reaction Steps

Synthesized as described in Example 39 from 4-chloro-2-(difluoromethyl)-1H-indole-5-carbonitrile and 5-[(2-bromoethyl)oxy]-2-fluoropyridine: MS (ESI) m/z 366 (M+1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07572820B2
Source datasetuspto-grants-2009_08
ORD IDord-f949e6d68d5745f884fb53d6f13e7ec9
Source noteuspto-grants-2009_08