Bromomethylcyclopropane → HCID 67406636, compound

HRID 2101978Notes

Reaction equation

HRID 2101978 reaction equation
[CH:1]1([C:4]2[NH:5][C:6]3[C:11]([CH:12]=2)=[C:10]([C:13]([F:16])([F:15])[F:14])[C:9]([C:17]#[N:18])=[CH:8][CH:7]=3)[CH2:3][CH2:2]1.Br[CH2:20][CH:21]1[CH2:23][CH2:22]1>>[CH:1]1([C:4]2[N:5]([CH2:20][CH:21]3[CH2:23][CH2:22]3)[C:6]3[C:11]([CH:12]=2)=[C:10]([C:13]([F:14])([F:15])[F:16])[C:9]([C:17]#[N:18])=[CH:8][CH:7]=3)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 81503BromomethylcyclopropaneHCID 674044722-cyclopropyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile

Product 1

HCID 67406636HCID 67406636, compound

Procedure

Synthesized as described in Example 4 using 2-cyclopropyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile and (bromomethyl)cyclopropane: 1H NMR (400 MHz, CDCl3) δ 7.48 (s, 2H), 6.37 (d, J=1.7 Hz, 1H), 4.19 (d, J=6.6 Hz, 2H), 1.92 (m, 1H), 1.24 (m, 1H), 1.11 (m, 2H), 0.86 (m, 2H), 0.61 (m, 2H), 0.39 (m, 2H); MS (ES) m/z 305 (M+1).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-39bdaf7c00e1458bae4ccfa1dc6ee509
Source dataset
uspto-grants-2009_08
Patent number
US07572820B2

Reaction notes

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