2-(Bromomethyl)-5-(trifluoromethyl)furan → 4-Chloro-2-ethyl-1-{[5-(trifluoromethyl)-2-furanyl]methyl}-1H-benzimidazole-5-carbonitrile

HRID 2102010Notes

Reaction equation

HRID 2102010 reaction equation
[Cl:1][C:2]1[C:10]2[N:9]=[C:8]([CH2:11][CH3:12])[NH:7][C:6]=2[CH:5]=[CH:4][C:3]=1[C:13]#[N:14].Br[CH2:16][C:17]1[O:18][C:19]([C:22]([F:25])([F:24])[F:23])=[CH:20][CH:21]=1>>[Cl:1][C:2]1[C:10]2[N:9]=[C:8]([CH2:11][CH3:12])[N:7]([CH2:16][C:17]3[O:18][C:19]([C:22]([F:25])([F:24])[F:23])=[CH:20][CH:21]=3)[C:6]=2[CH:5]=[CH:4][C:3]=1[C:13]#[N:14]

Participants

3

Reactant 2

HCID 27946052-(Bromomethyl)-5-(trifluoromethyl)furanHCID 674049024-chloro-2-ethyl-1H-benzimidazole-5-carbonitrile

Product 1

HCID 674075754-Chloro-2-ethyl-1-{[5-(trifluoromethyl)-2-furanyl]methyl}-1H-benzimidazole-5-carbonitrile

Procedure

Synthesized as described in Example 197B from 4-chloro-2-ethyl-1H-benzimidazole-5-carbonitrile and 2-(bromomethyl)-5-(trifluoromethyl)furan: MS (ESI) m/z 354 (M+1).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-915c196717aa41e9a52244d2983a7219
Source dataset
uspto-grants-2009_08
Patent number
US07572820B2

Reaction notes

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