3-Hydroxypyridine → 2-Methyl-1-[2-(3-pyridinyloxy)propyl]-4-(trifluoromethyl)-1H-indole-5-carbonitrile

HRID 2102167Notes

Reaction equation

HRID 2102167 reaction equation
[OH:1][CH:2]([CH3:20])[CH2:3][N:4]1[C:12]2[C:7](=[C:8]([C:15]([F:18])([F:17])[F:16])[C:9]([C:13]#[N:14])=[CH:10][CH:11]=2)[CH:6]=[C:5]1[CH3:19].[N:21]1[CH:26]=[CH:25][CH:24]=[C:23](O)[CH:22]=1>>[CH3:19][C:5]1[N:4]([CH2:3][CH:2]([O:1][C:23]2[CH:22]=[N:21][CH:26]=[CH:25][CH:24]=2)[CH3:20])[C:12]2[C:7]([CH:6]=1)=[C:8]([C:15]([F:18])([F:16])[F:17])[C:9]([C:13]#[N:14])=[CH:10][CH:11]=2

Participants

3

Reactant 2

HCID 79713-HydroxypyridineHCID 674038091-(2-Hydroxypropyl)-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile

Product 1

HCID 674067512-Methyl-1-[2-(3-pyridinyloxy)propyl]-4-(trifluoromethyl)-1H-indole-5-carbonitrile

Procedure

Synthesized as described in Example 139C using 1-(2-hydroxypropyl)-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile (Example 335) and 3-pyridinol; MS (ES) m/z 360 (M+1).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-08c06e41030b4e3186f3908aafc5277e
Source dataset
uspto-grants-2009_08
Patent number
US07572820B2

Reaction notes

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