Diethyl Ether → HCID 178506609, compound

HRID 2102291Notes

Reaction equation

HRID 2102291 reaction equation
O.[NH2:2][NH2:3].[IH:4].CS[C:7]1[NH:8][CH2:9][CH2:10][CH2:11][CH2:12][N:13]=1.CCOCC>CCO>[IH:4].[NH:13]1[CH2:12][CH2:11][CH2:10][CH2:9][NH:8][C:7]1=[N:2][NH2:3]

Participants

5

Reactant 3

HCID 3283Diethyl EtherHCID 24654Hydrazine hydrate (1:1)HCID 2011531H-1,3-Diazepine, 4,5,6,7-tetrahydro-2-methylthio-, hydriodide

Product 1

HCID 178506609HCID 178506609, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Hydrazine hydrate (0.44 ml, 7.23 mmol) was added to a solution of 2-(methylthio)-4,5,6,7-tetrahydro-1H-1,3-diazepine hydroiodide (1.79 d, 6.58 mmol) in EtOH (12 ml). The reaction mixture was refluxed for 5 h and cooled to r.t. Et2O was added and the product was collected by filtration, washed with Et2O and dried under vacuum to give 1.46 g (100%) crude title compound which was used directly in the next step.

Workup

  1. temperatureThe reaction mixture was refluxed for 5 h
  2. filtrationthe product was collected by filtration
  3. washwashed with Et2O
  4. customdried under vacuum

Sources & evidence

ORD record
ord-5c312eb231914c6d91a01dbe7943a349
Source dataset
uspto-grants-2009_08
Patent number
US07576077B2

Reaction notes

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