Dichloromethane → HCID 66970990, compound

HRID 2102318Notes

Reaction equation

HRID 2102318 reaction equation
C([O:8][C:9]1[C:13]([CH:14]([C:16]2[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[CH:18][CH:17]=2)O)=[C:12]([C:24]2[CH:29]=[CH:28][C:27]([O:30][CH3:31])=[CH:26][CH:25]=2)[N:11]([CH:32]([CH3:34])[CH3:33])[N:10]=1)C1C=CC=CC=1.ClCCl>C(O)C.[C].[Pd]>[CH:32]([N:11]1[C:12]([C:24]2[CH:25]=[CH:26][C:27]([O:30][CH3:31])=[CH:28][CH:29]=2)=[C:13]([CH2:14][C:16]2[CH:17]=[CH:18][C:19]([O:22][CH3:23])=[CH:20][CH:21]=2)[C:9](=[O:8])[NH:10]1)([CH3:33])[CH3:34]

Participants

5

Reactant 2

HCID 6344DichloromethaneHCID 66971319HCID 66971319, compound

Product 1

HCID 66970990HCID 66970990, compoundYield 89.9%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

To a solution of [3-benzyloxy-1-isopropyl-5-(4-methoxyphenyl)-1H-pyrazol-4-yl]4-methoxy-phenyl methanol (0.11 g) in ethanol (4 mL) was added a catalytic amount of 10% palladium-carbon powder and the mixture was stirred at room temperature under a hydrogen atmosphere overnight. Dichloromethane was added to the mixture and the insoluble material was removed by filtration. The solvent of filtrate was removed under reduced pressure to give the title compound (0.076 g).

Workup

  1. customthe insoluble material was removed by filtration
  2. customThe solvent of filtrate was removed under reduced pressure

Sources & evidence

ORD record
ord-69e7d50d58da4a2aa265435aa5ffaf47
Source dataset
uspto-grants-2009_08
Patent number
US07576063B2

Reaction notes

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