Hydrochloric Acid → HCID 68812963, compound

HRID 2102388Notes

Reaction equation

HRID 2102388 reaction equation
[C:1]([C:3]1([C:16]([N:18]2[CH2:23][CH2:22][O:21][CH2:20][CH2:19]2)=[O:17])[CH2:8][CH2:7][N:6](C(OC(C)(C)C)=O)[CH2:5][CH2:4]1)#[N:2].[ClH:24]>O1CCOCC1>[ClH:24].[N:18]1([C:16]([C:3]2([C:1]#[N:2])[CH2:8][CH2:7][NH:6][CH2:5][CH2:4]2)=[O:17])[CH2:19][CH2:20][O:21][CH2:22][CH2:23]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57803090tert-Butyl 4-cyano-4-(morpholin-4-ylcarbonyl)piperidine-1-carboxylate

Product 1

HCID 68812963HCID 68812963, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To tert-Butyl 4-cyano-4-(morpholin-4-ylcarbonyl)piperidine-1-carboxylate (I-2) (11.95 g, 40 mmole) was added 4M HCl in dioxane (80 mL). The resulting reaction mixture was stirred for 1 h at room temperature. After this time, LCMS indicated that the reaction was complete. The reaction was concentrated to afford the title compound (I-3) as a white solid. This product was pure enough for next step reaction. Analytical LCMS: single peak (214 nm), 0.548 min.

Workup

  1. customThe resulting reaction mixture
  2. concentrationThe reaction was concentrated

Sources & evidence

ORD record
ord-f434f6f21dcd4d3dafd833277de7a7cd
Source dataset
uspto-grants-2009_08
Patent number
US07576083B2

Reaction notes

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