Bromine → HCID 57803105, compound

HRID 2102487Notes

Reaction equation

HRID 2102487 reaction equation
[Cl:1][C:2]1[C:3]2[N:4]([CH:8]=[C:9]([C:11]3[CH:16]=[CH:15][CH:14]=[C:13]([O:17][CH3:18])[CH:12]=3)[N:10]=2)[CH:5]=[CH:6][N:7]=1.[Br:19]Br>C(O)(=O)C>[Br:19][C:8]1[N:4]2[CH:5]=[CH:6][N:7]=[C:2]([Cl:1])[C:3]2=[N:10][C:9]=1[C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([O:17][CH3:18])[CH:12]=1

Participants

4

Reactant 2

HCID 24408BromineHCID 578031348-Chloro-2-(3-methoxyphenyl)imidazo[1,2-a]pyrazine

Product 1

HCID 57803105HCID 57803105, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent2×

Procedure

To the product from example 170 in acetic acid (10 mL) was added a solution of bromine in acetic acid (0.25 mmol, 1 mL). Concentration of the reaction mixture afforded crude 3-bromo-8-chloro-2-(3-methoxy-phenyl)-imidazo[1,2-a]pyrazine. MH+ (LCMS) 338.0(m/z).

Sources & evidence

ORD record
ord-8a85253990a34709980ac78506dab0db
Source dataset
uspto-grants-2009_08
Patent number
US07576085B2

Reaction notes

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