反应详情

A mixture of N-benzylpiperazine dihydrochloride (2 g, 9.4 mmol), 2-bromo-1-(5-chloro-6-methoxynaphthalen-1-yl) ethanone (3.54 g, 11.3 mmol) and K2CO3 (4.55 g, 33 mmol) in acetone (120 ml) was treated according to the general preparation 2 to obtain N1-benzyl-N4-(5-chloro-6-methoxy-2-naphthoylmethyl) piperazine dihydro-chloride (2.85 g). The above product (2.6 g, 30 mmol) was reduced with NaBH4 (2.22 g, 60 mmol) in methanol (150 ml) according to the general preparation 3 to obtain 10.2 g of the title compound as white solid.

1. additionwas treated
2. customaccording to the general preparation 2