Piperazine → 1-[(4-Methoxyphenyl)methyl]piperazine--hydrogen chloride (1/2)

HRID 2102496Notes

Reaction equation

HRID 2102496 reaction equation
[CH3:1][O:2][C:3]1[CH:10]=[CH:9][C:6]([CH2:7][Cl:8])=[CH:5][CH:4]=1.[NH:11]1[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1>>[ClH:8].[ClH:8].[CH3:1][O:2][C:3]1[CH:10]=[CH:9][C:6]([CH2:7][N:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]2)=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 4837PiperazineHCID 699934-Methyloxybenzyl chloride

Product 1

HCID 122668061-[(4-Methoxyphenyl)methyl]piperazine--hydrogen chloride (1/2)Yield 75%

Procedure

A mixture of 4-methoxybenzylchlorine and piperazine was treated according to the general preparation 1 to obtain N-(4-methoxybenzyl) piperazine dihydrochloride, yield 75%, mp. 250-252° C. The N1-(4-methoxybenzyl)-N4-phenacyl piperazine dihydrochloride (0.5 g, 1.23 mmol) could be preparated according to the general preparation 2, and then reduced according to the general preparation 3 to obtain 0.38 g of the title compound, yield 77.55%, mp 244-246° C.).

Workup

  1. additionwas treated
  2. customaccording to the general preparation 1

Sources & evidence

ORD record
ord-2181379878a74bb98586217e9150c1cd
Source dataset
uspto-grants-2009_08
Patent number
US07576086B2

Reaction notes

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