Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | 2,6-Benzothiazolediamine | HCID 21504 | — |
| Reactant | 4,6-Dichloropyrimidine | HCID 70943 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 2-Isocyanato-1-methoxy-4-methylbenzene | HCID 4141520 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 86606143 | HCID 86606143 | — |
Reaction Steps
A mixture of 4,6-dichloropyrimidine (180 mg, 1.21 mmol), benzothiazole-2,6-diamine (200 mg, 1.21 mmol), sodium iodide (216 mg, 1.45 mmol), ethyl diisopropylamine (0.25 mL, 1.45 mmol) and DMF (10 mL) was heated at 85° C. for 3 h. 2-Methoxy-5-methylphenyl isocyanate (0.20 mL, 1.33 mmol) was added and heating was continued at 85° C. for 3 h. The solvent was removed and the residue treated with CH2Cl2. The precipitate was separated (0.57 g, 85%). LC/ESI-MS: m/z=441 [M+H]+; m/z=439 [M−H]−; Rt=3.64 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07576090B2 |
|---|
| Source dataset | uspto-grants-2009_08 |
|---|
| ORD ID | ord-35f2958e765b4eca8a5fa6a3190a51c4 |
|---|
| Source note | uspto-grants-2009_08 |
|---|
