反应详情

温度

85 °C

A mixture of 4,6-dichloropyrimidine (180 mg, 1.21 mmol), benzothiazole-2,6-diamine (200 mg, 1.21 mmol), sodium iodide (216 mg, 1.45 mmol), ethyl diisopropylamine (0.25 mL, 1.45 mmol) and DMF (10 mL) was heated at 85° C. for 3 h. 2-Methoxy-5-methylphenyl isocyanate (0.20 mL, 1.33 mmol) was added and heating was continued at 85° C. for 3 h. The solvent was removed and the residue treated with CH2Cl2. The precipitate was separated (0.57 g, 85%). LC/ESI-MS: m/z=441 [M+H]+; m/z=439 [M−H]−; Rt=3.64 min.

1. temperatureheating
2. customThe solvent was removed
3. additionthe residue treated with CH2Cl2
4. customThe precipitate was separated (0.57 g, 85%)