4-Chloro-6,7-dimethoxyquinazoline → HCID 23132491, compound

HRID 2102820Notes

Reaction equation

HRID 2102820 reaction equation
[NH2:1][C:2]1[CH:19]=[CH:18][C:5]2[N:6]=[C:7]([NH:9][C:10](=[O:17])[C:11]3[CH:16]=[CH:15][CH:14]=[N:13][CH:12]=3)[S:8][C:4]=2[CH:3]=1.Cl[C:21]1[C:30]2[C:25](=[CH:26][C:27]([O:33][CH3:34])=[C:28]([O:31][CH3:32])[CH:29]=2)[N:24]=[CH:23][N:22]=1>C(O)C>[CH3:32][O:31][C:28]1[CH:29]=[C:30]2[C:25](=[CH:26][C:27]=1[O:33][CH3:34])[N:24]=[CH:23][N:22]=[C:21]2[NH:1][C:2]1[CH:19]=[CH:18][C:5]2[N:6]=[C:7]([NH:9][C:10](=[O:17])[C:11]3[CH:16]=[CH:15][CH:14]=[N:13][CH:12]=3)[S:8][C:4]=2[CH:3]=1

Participants

4

Reactant 2

HCID 27693644-Chloro-6,7-dimethoxyquinazolineHCID 16787143HCID 16787143, compound

Product 1

HCID 23132491HCID 23132491, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

N-[6-(6,7-Dimethoxyquinazolin-4-ylamino)benzothiazol-2-yl]nicotinamide was prepared by heating a mixture of N-(6-aminobenzothiazol-2-yl)nicotinamide (IM 4, 30 mg, 0.111 mmol) and 4-chloro-6,7-dimethoxyquinazoline (Fluorochem, 25 mg, 0.111 mmol) in ethanol (3 mL) to 80° C. for 2 h. The resulting precipitate was separated by filtration, washed with ethanol and dried (yellow solid, 44 mg, 96 μmol, 87%), LC/ESI-MS: m/z=459 [M+H]+; m/z=457 [M+H]−; Rt=2.60 min.

Workup

  1. temperatureby heating
  2. customThe resulting precipitate was separated by filtration
  3. washwashed with ethanol
  4. customdried (yellow solid, 44 mg, 96 μmol, 87%), LC/ESI-MS

Sources & evidence

ORD record
ord-a24fff7f6a1644c5a1c9689399ac51de
Source dataset
uspto-grants-2009_08
Patent number
US07576090B2

Reaction notes

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