4-Chloro-6,7-dimethoxyquinazoline → HCID 23132491, compound

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Reaction Steps

N-[6-(6,7-Dimethoxyquinazolin-4-ylamino)benzothiazol-2-yl]nicotinamide was prepared by heating a mixture of N-(6-aminobenzothiazol-2-yl)nicotinamide (IM 4, 30 mg, 0.111 mmol) and 4-chloro-6,7-dimethoxyquinazoline (Fluorochem, 25 mg, 0.111 mmol) in ethanol (3 mL) to 80° C. for 2 h. The resulting precipitate was separated by filtration, washed with ethanol and dried (yellow solid, 44 mg, 96 μmol, 87%), LC/ESI-MS: m/z=459 [M+H]+; m/z=457 [M+H]−; Rt=2.60 min.

Provenance & Evidence