Water → HCID 57804140, compound

HRID 2102929Notes

Reaction equation

HRID 2102929 reaction equation
[F:1][C:2]1[CH:11]=[C:10]([C:12]#[C:13][C:14]([CH3:17])([CH3:16])[CH3:15])[CH:9]=[CH:8][C:3]=1[C:4]([O:6]C)=[O:5].O.[OH-].[Li+]>CO>[CH3:15][C:14]([CH3:17])([CH3:16])[C:13]#[C:12][C:10]1[CH:9]=[CH:8][C:3]([C:4]([OH:6])=[O:5])=[C:2]([F:1])[CH:11]=1

Participants

5

Reactant 3

HCID 962WaterHCID 3939Lithium HydroxideHCID 68701774HCID 68701774, compound

Product 1

HCID 57804140HCID 57804140, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Methyl 2-fluoro-4-(3,3-dimethylbut-1-ynyl)benzoate (8.2 g, 0.035 mol) was suspended in a 3:1 mixture of H2O and methanol to which was added lithium hydroxide (2.5 g, 0.10 mol) all at once and the mixture was agitated over-night at ambient temperature. The mixture was then concentrated to ¾ the volume and acidified with 1N HCl until the pH read just acidic. The white precipitate was filtered, washed with water and vacuum dried at 80° C. for several hours. m/z=218.9 (M−1).

Workup

  1. concentrationThe mixture was then concentrated
  2. filtrationThe white precipitate was filtered
  3. washwashed with water and vacuum
  4. customdried at 80° C. for several hours

Sources & evidence

ORD record
ord-1eec47d44aaf4de08ebe8f27e2f1e063
Source dataset
uspto-grants-2009_08
Patent number
US07576099B2

Reaction notes

Loading…