Sodium Hydroxide → HCID 57804160, compound

HRID 2102937Notes

Reaction equation

HRID 2102937 reaction equation
[F:1][C:2]1[C:11]([O:12][CH3:13])=[C:10]([C:14]#[C:15][C:16]([CH3:19])([CH3:18])[CH3:17])[CH:9]=[CH:8][C:3]=1[C:4]([O:6]C)=[O:5].[OH-].[Na+]>CO>[F:1][C:2]1[C:11]([O:12][CH3:13])=[C:10]([C:14]#[C:15][C:16]([CH3:19])([CH3:18])[CH3:17])[CH:9]=[CH:8][C:3]=1[C:4]([OH:6])=[O:5]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 57804198HCID 57804198, compound

Product 1

HCID 57804160HCID 57804160, compoundYield 112.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
50 °C

Procedure

Methyl 2-fluoro-3-methoxy-4-(3,3-dimethylbut-1-ynyl)benzoate (760 mg, 2.7 mmol) was dissolved in MeOH (10 mL), NaOH (in 10 mL water) was added and stirred at 50° C. for 1 h. Solvent was removed, more water was added, neutralized by HCl till pH˜2, white solid thus formed was filtered out, dried in vacuum oven (at 65° C.). Product was obtained as a white solid (760 mg, 93%).

Workup

  1. customSolvent was removed
  2. additionmore water was added
  3. customthus formed
  4. filtrationwas filtered out
  5. customdried in vacuum oven (at 65° C.)

Sources & evidence

ORD record
ord-6c08e09326cf43b3904ff269df414e0d
Source dataset
uspto-grants-2009_08
Patent number
US07576099B2

Reaction notes

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