HCID 68703275, compound → 7-Amino-3-quinolinemethanol

HRID 2102962Notes

Reaction equation

HRID 2102962 reaction equation
[OH:1][CH2:2][C:3]1[CH:4]=[N:5][C:6]2[C:11]([CH:12]=1)=[CH:10][CH:9]=[C:8]([NH:13]C(=O)OCC1C=CC=CC=1)[CH:7]=2>[Pd].CO>[NH2:13][C:8]1[CH:7]=[C:6]2[C:11]([CH:12]=[C:3]([CH2:2][OH:1])[CH:4]=[N:5]2)=[CH:10][CH:9]=1

Participants

4

Reactant 1

HCID 68703275HCID 68703275, compound

Product 1

HCID 590206577-Amino-3-quinolinemethanol

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of benzyl 3-(hydroxymethyl)quinolin-7-ylcarbamate (480 mg, 0.0016 mol), 10% Pd-C (50 mg), and MeOH (50 mL) was stirred under H2 (1 atm) for 1 h. The catalyst was filtered-off and the filtrate was concentrated to give the product as a yellow solid. LC-MS: 0.34 min, 175.1 (M+1).

Workup

  1. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-e762c4d1547747cf8c266e8ca536ca4e
Source dataset
uspto-grants-2009_08
Patent number
US07576099B2

Reaction notes

Loading…