反应详情

温度

200 °C

A solution of 6-hydroxy-7,8-dimethyl-4H-spiro[chromene-3, 1′-cyclopropan]-4-one (10 mg), prepared as described above, methoxyamine hydrochloride (110 mg) in pyridine (3 mL) was stirred in a microwave reaction tube (200° C., 30 min). After cooling down, the mixture was partitioned between water and ethylacetate, and the organic layer was washed with dil. HCl, dried, and evaporated. The residue was purified by silica gel column eluting with 15% EtOAc in hexane to give a 3.6 mg of 6-hydroxy-7,8-dimethylspiro[chroman-3,1′-cyclopropan]-4-one O-methyl oxime.

1. temperatureAfter cooling down
2. customthe mixture was partitioned between water and ethylacetate
3. washthe organic layer was washed with dil. HCl
4. customdried
5. customevaporated
6. customThe residue was purified by silica gel column
7. washeluting with 15% EtOAc in hexane