反应详情

2,6-Dimethyl-4-nitroaniline (15 g) Me2SO4 (22 g) and K2CO3 (23 g) were dissolved in 150 mL acetone and refluxed for 3 hours. The reaction mixture was filtered and concentrated. The organic residue was dissolved in warm hexane and let to crystallize out in the fridge. After filtration, 2-methoxy-1,3-dimethyl-5-nitrobenzene was collected as white solid (12 g). 1H-NMR (300 MHz, CDCl3): δ=7.95 (s, 2H), 3.80 (s, 3H), 2.38 (s, 6H) ppm. MS: m/z 182 (100, M+H)+

1. temperaturerefluxed for 3 hours
2. filtrationThe reaction mixture was filtered
3. concentrationconcentrated
4. dissolutionThe organic residue was dissolved in warm hexane
5. customto crystallize out in the fridge
6. filtrationAfter filtration, 2-methoxy-1,3-dimethyl-5-nitrobenzene
7. customwas collected as white solid (12 g)