Water → 1-(2-Fluoro-4,5-dimethoxy-benzenesulfonyl)-piperidine

HRID 2103137Notes

Reaction equation

HRID 2103137 reaction equation
[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[F:7][C:8]1[CH:13]=[C:12]([O:14][CH3:15])[C:11]([O:16][CH3:17])=[CH:10][C:9]=1[S:18](Cl)(=[O:20])=[O:19].O>ClCCl>[F:7][C:8]1[CH:13]=[C:12]([O:14][CH3:15])[C:11]([O:16][CH3:17])=[CH:10][C:9]=1[S:18]([N:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1)(=[O:19])=[O:20]

Participants

5

Reactant 3

HCID 962WaterHCID 8082PiperidineHCID 167850042-Fluoro-4,5-dimethoxybenzene-1-sulfonyl chloride

Product 1

HCID 224750541-(2-Fluoro-4,5-dimethoxy-benzenesulfonyl)-piperidine

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

Piperidine (4.15 ml, 42.02 mmol) was slowly added to a cooled (ice-bath) solution of 2-fluoro-4,5-dimethoxy-benzenesulfonyl chloride (5 g, 19.63 mmol) in dichloromethane (110 mL). The mixture was stirred overnight at room temperature, diluted with dichloromethane and poured into water. The aqueous phase was extracted with dichloromethane and the combined organic phases washed with brine, dried over magnesium sulfate and evaporated. The crude product was used without further purification.

Workup

  1. extractionThe aqueous phase was extracted with dichloromethane
  2. washthe combined organic phases washed with brine
  3. dry with materialdried over magnesium sulfate
  4. customevaporated
  5. customThe crude product was used without further purification

Sources & evidence

ORD record
ord-976572d93c5d4970ad6ca8f3cdc67c4d
Source dataset
uspto-grants-2009_08
Patent number
US07576088B2

Reaction notes

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