HCID 14579587, compound → 3,3',5,5'-Tetrafluorobenzophenone

HRID 2103144Notes

Reaction equation

HRID 2103144 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:9]([C:11]2[CH:16]=[C:15]([F:17])[CH:14]=[C:13]([F:18])[CH:12]=2)[OH:10])[CH:5]=[C:6]([F:8])[CH:7]=1>O=[Mn]=O.ClCCCl>[F:1][C:2]1[CH:3]=[C:4]([C:9]([C:11]2[CH:16]=[C:15]([F:17])[CH:14]=[C:13]([F:18])[CH:12]=2)=[O:10])[CH:5]=[C:6]([F:8])[CH:7]=1

Participants

4

Reactant 1

HCID 14579587HCID 14579587, compound

Product 1

HCID 27605693,3',5,5'-TetrafluorobenzophenoneYield 95%

Reagents, catalysts & solvents 2

HCID 14801Manganese dioxideCatalystHCID 111,2-DichloroethaneSolvent

Procedure

1.56 g bis-(3,5-difluoro-phenyl)-methanol, 1.06 g MnO2 and 36 mL 1,2-dichloroethane were refluxed for 4 hours. The mixture was cooled, filtered and evaporated. Chromatography of the residue afforded 1.47 g of a white solid, m.p.: 79° C.; MS: 254 ([M]+).

Workup

  1. temperatureThe mixture was cooled
  2. filtrationfiltered
  3. customevaporated

Sources & evidence

ORD record
ord-fe74bff6832c47928d5ee8e42aab619a
Source dataset
uspto-grants-2009_08
Patent number
US07576088B2

Reaction notes

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