(2-Fluoro-4,5-dihydroxy-phenyl)-morpholin-4-yl-methanone → [2,2-Bis-(3-bromo-phenyl)-6-fluoro-benzo[1,3]dioxol-5-yl]-morpholin-4-yl-methanone

HRID 2103152Notes

Reaction equation

HRID 2103152 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([C:8]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([Br:17])[CH:12]=2)(Cl)Cl)[CH:5]=[CH:6][CH:7]=1.[F:18][C:19]1[CH:24]=[C:23]([OH:25])[C:22]([OH:26])=[CH:21][C:20]=1[C:27]([N:29]1[CH2:34][CH2:33][O:32][CH2:31][CH2:30]1)=[O:28]>>[Br:1][C:2]1[CH:3]=[C:4]([C:8]2([C:11]3[CH:16]=[CH:15][CH:14]=[C:13]([Br:17])[CH:12]=3)[O:25][C:23]3[CH:24]=[C:19]([F:18])[C:20]([C:27]([N:29]4[CH2:34][CH2:33][O:32][CH2:31][CH2:30]4)=[O:28])=[CH:21][C:22]=3[O:26]2)[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 21865388(2-Fluoro-4,5-dihydroxy-phenyl)-morpholin-4-yl-methanoneHCID 22475041Bis-(3-bromophenyl)-dichloromethane

Product 1

HCID 22475034[2,2-Bis-(3-bromo-phenyl)-6-fluoro-benzo[1,3]dioxol-5-yl]-morpholin-4-yl-methanone

Procedure

79 mg bis-(3-bromophenyl)-dichloromethane and 48 mg (2-fluoro-4,5-dihydroxy-phenyl)-morpholin-4-yl-methanone were heated to 180° C. for one hour. Chromatography of the dark residue gave 30 mg of an off-white waxy solid, MS: m/e=564 ([M+H])+.

Workup

  1. customChromatography of the dark residue gave 30 mg of an off-white waxy solid, MS

Sources & evidence

ORD record
ord-418a3df3e5ac47e9a5f5968de592f3cc
Source dataset
uspto-grants-2009_08
Patent number
US07576088B2

Reaction notes

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