HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2-Fluoro-4,5-dihydroxy-phenyl)-morpholin-4-yl-methanone → [2,2-Bis-(3-bromo-phenyl)-6-fluoro-benzo[1,3]dioxol-5-yl]-morpholin-4-yl-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2-Fluoro-4,5-dihydroxy-phenyl)-morpholin-4-yl-methanone | HCID 21865388 | — |
| Reactant | Bis-(3-bromophenyl)-dichloromethane | HCID 22475041 | — |
| Product | [2,2-Bis-(3-bromo-phenyl)-6-fluoro-benzo[1,3]dioxol-5-yl]-morpholin-4-yl-methanone | HCID 22475034 | — |
Reaction Steps
79 mg bis-(3-bromophenyl)-dichloromethane and 48 mg (2-fluoro-4,5-dihydroxy-phenyl)-morpholin-4-yl-methanone were heated to 180° C. for one hour. Chromatography of the dark residue gave 30 mg of an off-white waxy solid, MS: m/e=564 ([M+H])+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07576088B2 |
| Source dataset | uspto-grants-2009_08 |
| ORD ID | ord-418a3df3e5ac47e9a5f5968de592f3cc |
| Source note | uspto-grants-2009_08 |